Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Biochemical and Biophysical Research Communications Année : 2007

Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells

Résumé

Adipocyte dysfunction is strongly associated with the development of cardiovascular risk factors and diabetes. It is accepted that the regulation of adipogenesis or adipokines expression, notably adiponectin, is able to prevent these disorders. In this report, we show that phloretin, a dietary flavonoid, enhances 3T3-L1 adipocyte differentiation as evidenced by increased triglyceride accumulation and GPDH activity. At a molecular level, mRNA expression levels of both PPARγ and C/EBPα, the master adipogenic transcription factors, are markedly increased by phloretin. Moreover, mRNA levels of PPARγ target genes such as LPL, aP2, CD36 and LXRα are up-regulated by phloretin. We also show that phloretin enhances the expression and secretion of adiponectin. Co-transfection studies suggest the induction of PPARγ transcriptional activity as a possible mechanism underlying the phloretin-mediated effects. Taken together, these results suggest that phloretin may be beneficial for reducing insulin resistance through its potency to regulate adipocyte differentiation and function

Dates et versions

hal-02666144 , version 1 (31-05-2020)

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Citer

Meryl Hassan, Claire El Yazidi, Jean-Francois Landrier, Denis Lairon, Alain Margotat, et al.. Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells. Biochemical and Biophysical Research Communications, 2007, 361 (1), pp.208-213. ⟨10.1016/j.bbrc.2007.07.021⟩. ⟨hal-02666144⟩
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