Apparent elimination of EIAV ancestral species in a long-term inapparent carrier - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Virology Année : 2006

Apparent elimination of EIAV ancestral species in a long-term inapparent carrier

Résumé

Equine infectious anemia virus (EIAV) envelope variation produces newly dominant quasispecies with each sequential disease cycle; new populations arise, and previous plasma quasispecies, including the original inoculum, become undetectable. The question remains whether these ancestral variants exist in tissue reservoirs or if the immune system eliminates quasispecies from persistent infections. To examine this, an EIAV long-term inapparent carrier was immune suppressed with dexamethasone. Immune suppression resulted in increased plasma viral loads by approximately 104 fold. Characterization of pre- and post-immune suppression populations demonstrated continual envelope evolution and revealed novel quasispecies distinct from defined populations from previous disease stages. Analysis of the tissue and plasma populations post-immune suppression indicated the original infectious inoculum and early populations were undetectable. Therefore, the host immune system apparently eliminated a diverse array of antigenic variants, but viral persistence was maintained by relentless evolution of new envelope populations from tissue reservoirs in response to ongoing immune pressures.

Dates et versions

hal-02667720 , version 1 (31-05-2020)

Identifiants

Citer

Jodi K. Craigo, Timothy J. Sturgeon, Sheila J. Cook, Charles J. Issel, Caroline Leroux, et al.. Apparent elimination of EIAV ancestral species in a long-term inapparent carrier. Virology, 2006, 344 (2), pp.340-353. ⟨10.1016/j.virol.2005.09.006⟩. ⟨hal-02667720⟩
13 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More