EUGE`NE’HOM is a gene prediction software for eukaryotic organisms based on comparative analysis. EUGE` NE’HOM is able to take into account multiple homologous sequences from more or less closely related organisms. It integrates the results of TBLASTX analysis, splice site and start codon prediction and a robust coding/non-coding probabilistic model which allows EUGE`NE’HOM to handle sequences from a variety of organisms. The current target of EUGE`NE’HOM is plant sequences. The EUGE`NE’HOM web site is available at http://genopole. toulouse.inra.fr/bioinfo/eugene/EuGeneHom/cgi-bin/EuGeneHom.pl.