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Article Dans Une Revue SIAM Journal on Applied Mathematics Année : 2013

Dynamic behavior of stochastic gene expression models in the presence of bursting

Résumé

This paper considers the behavior of discrete and continuous mathematical models for gene expression in the presence of transcriptional/translational bursting. We treat this problem in generality with respect to the distribution of the burst size as well as the frequency of bursting, and our results are applicable to both inducible and repressible expression patterns in prokaryotes and eukaryotes. We have given numerous examples of the applicability of our results, especially in the experimentally observed situation that burst size is geometrically or exponentially distributed.

Domaines

Autre [q-bio.OT]
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Dates et versions

hal-02650825 , version 1 (29-05-2020)

Identifiants

Citer

M.C. Mackey, M. Tyran-Kamińska, Romain Yvinec. Dynamic behavior of stochastic gene expression models in the presence of bursting. SIAM Journal on Applied Mathematics, 2013, 73 (5), pp.1830-1852. ⟨10.1137/12090229X⟩. ⟨hal-02650825⟩
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