Chemical Analysis and Antihyperglycemic Activity of an Original Extract from Burdock Root (Arctium lappa) - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Journal of Agricultural and Food Chemistry Année : 2014

Chemical Analysis and Antihyperglycemic Activity of an Original Extract from Burdock Root (Arctium lappa)

Résumé

In the present study, we obtained a dried burdock root extract (DBRE) rich in caffeoylquinic acids derivatives. We performed the chemical characterization of DBRE and explored its antihyperglycemic potential in both in vitro and in vivo experiments. Chemical analysis of DBRE using LC-MS and GC-MS revealed the presence of a great majority of dicaffeoylquinic acid derivatives (75.4%) of which 1,5-di-O-caffeoyl-4-O-maloylquinic acid represents 4496 of the extract. In the in vitro experiments, DBRE is able to increase glucose uptake in cultured L6 myocytes and to decrease glucagon-induced glucose output from rat isolated hepatocytes together with a reduction of hepatic glucose 6-phosphatase activity. DBRE did not increase insulin secretion in the INS-1 pancreatic beta-cell line. In vivo, DBRE improves glucose tolerance both after intraperitoneal and oral subchronic administration. In conclusion, our data demonstrate that DBRE constitutes an original set of caffeoylquinic acid derivatives displaying antihyperglycemic properties.
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Dates et versions

hal-01268818 , version 1 (04-02-2016)

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Didier Tousch, Luc Bidel, Guillaume Cazals, Karine Ferrare, Jeremy Leroy, et al.. Chemical Analysis and Antihyperglycemic Activity of an Original Extract from Burdock Root (Arctium lappa). Journal of Agricultural and Food Chemistry, 2014, 62 (31), pp.7738 - 7745. ⟨10.1021/jf500926v⟩. ⟨hal-01268818⟩
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