Polymorphisms in twelve candidate genes are associated with growth, muscle lipid profile and meat quality traits in eleven European cattle breeds
Natalia Sevane
(1)
,
E. Armstrong
(2)
,
P. Wiener
(3)
,
R. Pong Wong
(3)
,
S. Dunner
(1)
,
P. Alberti
(4)
,
Valérie Amarger
(5)
,
Didier Delourme
(5)
,
Hubert H. Levéziel
(5)
,
Simon S. Boitard
(6)
,
Brigitte B. Mangin
(7)
,
J. Canon
(8)
,
M.L. Checa
(8)
,
Susana Dunner
(8)
,
David Garcia
(8)
,
M.E. Miranda
(8)
,
R. Pérez
(8)
,
M. Christensen
(9)
,
A. Crisa
(9)
,
Cinzia Marchitelli
(10)
,
A. Valentini
(10)
,
S. Failla
(11)
,
S. Gigli
(11)
,
Jean-François J.-F. Hocquette
(12)
,
G. Nute
(13)
,
I. Richardson
(13)
,
J.L. Olleta
(14)
,
Begoña Panea
(14)
,
Carlos Sanudo
(14)
,
N. Razzaq
(15)
,
Gilles G. Renand
(16)
,
J.L. Williams
(17)
1
UCM -
Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
2 UDELAR - Universidad de la República [Montevideo]
3 Edin. - University of Edinburgh
4 CITA - Centro de Investigación y Tecnología Agroalimentaria de Aragón
5 UMR GMA - Unité de Génétique Moléculaire Animale
6 GenPhySE - Génétique Physiologie et Systèmes d'Elevage
7 Unité mixte de recherche interactions plantes-microorganismes
8 Departamento de Producción Animal, Facultad de Veterinaria
9 UCPH - University of Copenhagen = Københavns Universitet
10 Département de Production Animale
11 Istituto Sperimentale per la Zootecnia
12 UMRH - Unité Mixte de Recherche sur les Herbivores - UMR 1213
13 Division of Farm Animal Science
14 University of Zaragoza - Universidad de Zaragoza [Zaragoza]
15 The Roslin Institute
16 GABI - Génétique Animale et Biologie Intégrative
17 Parco Tecnologico Padano
2 UDELAR - Universidad de la República [Montevideo]
3 Edin. - University of Edinburgh
4 CITA - Centro de Investigación y Tecnología Agroalimentaria de Aragón
5 UMR GMA - Unité de Génétique Moléculaire Animale
6 GenPhySE - Génétique Physiologie et Systèmes d'Elevage
7 Unité mixte de recherche interactions plantes-microorganismes
8 Departamento de Producción Animal, Facultad de Veterinaria
9 UCPH - University of Copenhagen = Københavns Universitet
10 Département de Production Animale
11 Istituto Sperimentale per la Zootecnia
12 UMRH - Unité Mixte de Recherche sur les Herbivores - UMR 1213
13 Division of Farm Animal Science
14 University of Zaragoza - Universidad de Zaragoza [Zaragoza]
15 The Roslin Institute
16 GABI - Génétique Animale et Biologie Intégrative
17 Parco Tecnologico Padano
Valérie Amarger
- Fonction : Auteur
- PersonId : 746830
- IdHAL : valerie-amarger
- ORCID : 0000-0001-9258-6675
- IdRef : 081794843
Simon S. Boitard
- Fonction : Auteur
- PersonId : 736344
- IdHAL : simon-boitard
- ORCID : 0000-0002-2499-5052
- IdRef : 114957460
Jean-François J.-F. Hocquette
- Fonction : Auteur
- PersonId : 737280
- IdHAL : jean-francois-hocquette
- ORCID : 0000-0003-2409-3881
- IdRef : 079209173
Résumé
Current customers' demands focus on the nutritional and sensory quality of cattle meat. Candidate gene approach allows identification of genetic polymorphisms that have a measurable effect on traits of interest. The aim of this work is to identify new molecular markers for beef production through an association study using 27 candidate genes and 314 purebred bulls from 11 European cattle breeds. Twelve genes were found associated with different lipid and meat quality traits, and among these stand out the considerable effect of CAST on fatness score, CGGBP1 on growth traits, HSPB1 on the percentage of lauric acid (12:0) and phospholipid docosahexaenoic acid (DHA 22:6 n - 3), RORA on the ratio of light absorption (K) to light scattering (S) (K/S), and TNFA on lightness (L*). Most of these traits are related to post-mortem muscle biochemical changes, which are key factors controlling meat quality and consumers' acceptance. Also, the variations produced on muscle fatty acid profiles, such as those of AANAT, CRH, CSN3, HSPB1, and TNFA, give insights into the genetic networks controlling these complex traits and the possibility of future improvement of meat nutritional quality.