Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance

Cardiovascular complications of obesity and diabetes are major health problems. Assessing their development, their link with ectopic fat deposition and their flexibility with therapeutic intervention is essential. The aim of this study was to longitudinally investigate cardiac alterations and ectopic fat accumulation associated with diet-induced obesity using multimodal cardiovascular magnetic resonance (CMR) in mice. The second objective was to monitor cardiac response to exendin-4 (GLP-1 receptor agonist).

Mots clés

Obesity Longitudinal study Proton-magnetic resonance spectroscopy Cardiovascular magnetic resonance crmbm Diabetes DIO mice model

Domaines

Ingénierie biomédicale

Fichier principal

AbdesselamJCMR2015.pdf (1.9 Mo)

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https://amu.hal.science/hal-01414315

Soumis le : mercredi 16 mai 2018-10:38:38

Dernière modification le : jeudi 1 février 2024-14:20:15

Archivage à long terme le : lundi 24 septembre 2018-11:26:22

Dates et versions

hal-01414315 , version 1 (16-05-2018)

Identifiants

HAL Id : hal-01414315 , version 1
DOI : 10.1186/s12968-015-0198-x
PRODINRA : 357227
PUBMED : 26546347
WOS : 000364186300001

Citer

Inès Abdesselam, Pauline Pepino, Thomas Troalen, Michael Macia, Patricia Ancel, et al.. Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 2015, 17 (1), pp.95. ⟨10.1186/s12968-015-0198-x⟩. ⟨hal-01414315⟩

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