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Article Dans Une Revue (Article De Synthèse) Trends in Parasitology Année : 2015

Regulation of the immune response to α-Gal and vector-borne diseases

Résumé

Vector-borne diseases (VBD) challenge our understanding of emerging diseases. Recently, arthropod vectors have been involved in emerging anaphylactic diseases. In particular, the immunoglobulin E (IgE) antibody response to the carbohydrate Gala1-3Galb1-(3)4GlcNAc-R (a-gal) following a tick bite was associated with allergies to red meat, cetuximab, and gelatin. By contrast, an anti-a-gal IgM antibody response was shown to protect against mosquito-borne malaria. Herein, we highlight the interplay between the gut microbiota, vectors, transmitted pathogens, and the regulation of the immune response as a model to understand the protective or allergic effect of a-gal. Establishing the source of a-gal in arthropod vectors and the immune response to vector bites and transmitted pathogens will be essential for diagnosing, treating, and ultimately preventing these emerging anaphylactic and other vector-borne diseases.
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Dates et versions

hal-02630209 , version 1 (27-05-2020)

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Alejandro Cabezas-Cruz, Lourdes Mateos-Hernandez, Magdiel Pérez-Cruz, James J. Valdes, Isabel G. Fernández De Mera, et al.. Regulation of the immune response to α-Gal and vector-borne diseases. Trends in Parasitology, 2015, 31 (10), pp.470-476. ⟨10.1016/j.pt.2015.06.016⟩. ⟨hal-02630209⟩
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