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Article Dans Une Revue Parasitology Année : 2010

Graph methods for the investigation of metabolic networks in parasitology

Ludovic Cottret
Fabien Jourdan

Résumé

Recently, a way was opened with the development of many mathematical methods to model and analyze genome-scale metabolic networks. Among them, methods based on graph models enable to us quickly perform large-scale analyses on large metabolic networks. However, it could be difficult for parasitologists to select the graph model and methods adapted to their biological questions. In this review, after briefly addressing the problem of the metabolic network reconstruction, we propose an overview of the graph-based approaches used in whole metabolic network analyses. Applications highlight the usefulness of this kind of approach in the field of parasitology, especially by suggesting metabolic targets for new drugs. Their development still represents a major challenge to fight against the numerous diseases caused by parasites.

Dates et versions

hal-02661590 , version 1 (30-05-2020)

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Ludovic Cottret, Fabien Jourdan. Graph methods for the investigation of metabolic networks in parasitology. Parasitology, 2010, 137, pp.1393-1407. ⟨10.1017/S0031182010000363⟩. ⟨hal-02661590⟩
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