Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
M. M. Ulaszewska
(1)
,
C. H. Weinert
(2)
,
A. Trimigno
(3)
,
R. Portmann
(4)
,
C. Andres Lacueva
(5, 6, 7, 8)
,
R. Badertscher
(4)
,
L. Brennan
(9, 10)
,
C. Brunius
(11)
,
A. Bub
(12)
,
F. Capozzi
(3)
,
M. Cialie Rosso
(13)
,
C. E. Cordero
(13)
,
H. Daniel
(14)
,
Stéphanie Durand
(15, 16)
,
B. Egert
(2)
,
P. G. Ferrario
(3)
,
E. J. M. Feskens
(17)
,
P. Franceschi
(18)
,
M. Garcia-Aloy
(5, 6, 7, 8)
,
Franck Giacomoni
(15, 16)
,
P. Giesbertz
(19)
,
R. Gonzalez-Dominguez
(5, 6, 7, 8)
,
K. Hanhineva
(20, 21)
,
L. Y. Hemeryck
(22, 23)
,
J. Kopka
(24)
,
S. E. Kulling
(2)
,
R. Llorach
(5, 6, 7, 8)
,
Claudine Manach
(15)
,
F. Mattivi
(1, 25, 26)
,
Carole Migné
(15, 16)
,
L. H. Munger
(27)
,
B. Ott
(28, 29, 30)
,
G. Picone
(3)
,
G. Pimentel
(27)
,
Estelle Pujos-Guillot
(15, 16)
,
S. Riccadonna
(18)
,
M. J. Rist
(3)
,
C. Rombouts
(22, 23)
,
J. Rubert
(1)
,
T. Skurk
(28, 29, 30)
,
P. S. C. Sri Harsha
(9, 10)
,
L. van Meulebroek
(22, 23)
,
L. Vanhaecke
(22, 23)
,
R. Vazquez-Fresno
(31)
,
D. Wishart
(31)
,
G. Vergeres
(27)
1
Department of Food Quality and Nutrition
2 Department of Safety and Quality of Fruit and Vegetables
3 Department of Agricultural and Food Science
4 Method Development and Analytics Research Division
5 Department of Nutrition and Food Sciences
6 UB - Universitat de Barcelona
7 Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable
8 ISC - Instituto de Salud Carlos III [Madrid]
9 Institute of Food and Health
10 UCD - University College Dublin [Dublin]
11 Department of Biology and Biological Engineering
12 Department of Physiology and Biochemistry of Nutrition
13 Dipartimento di Scienza e Tecnologia
14 Nutritional Physiology
15 UNH - Unité de Nutrition Humaine
16 PFEM - Plateforme Exploration du Métabolisme
17 Division of Human Nutrition
18 CBU - Computational Biology Unit [Bergen]
19 Molecular Nutrition Unit
20 Department of Clinical Nutrition
21 University of Eastern Finland
22 Department of Veterinary Public Health and Food Safety
23 UGENT - Universiteit Gent = Ghent University
24 Department of Molecular Physiology, Applied Metabolome Analysis
25 Center Agriculture Food Environment
26 UNITN - Università degli Studi di Trento = University of Trento
27 Food Microbial Systems Research Division
28 Else Kröner Fresenius Center for Nutritional Medicine
29 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
30 ZIEL Institute for Food and Health
31 Departments of Biological Sciences and Computing Science
2 Department of Safety and Quality of Fruit and Vegetables
3 Department of Agricultural and Food Science
4 Method Development and Analytics Research Division
5 Department of Nutrition and Food Sciences
6 UB - Universitat de Barcelona
7 Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable
8 ISC - Instituto de Salud Carlos III [Madrid]
9 Institute of Food and Health
10 UCD - University College Dublin [Dublin]
11 Department of Biology and Biological Engineering
12 Department of Physiology and Biochemistry of Nutrition
13 Dipartimento di Scienza e Tecnologia
14 Nutritional Physiology
15 UNH - Unité de Nutrition Humaine
16 PFEM - Plateforme Exploration du Métabolisme
17 Division of Human Nutrition
18 CBU - Computational Biology Unit [Bergen]
19 Molecular Nutrition Unit
20 Department of Clinical Nutrition
21 University of Eastern Finland
22 Department of Veterinary Public Health and Food Safety
23 UGENT - Universiteit Gent = Ghent University
24 Department of Molecular Physiology, Applied Metabolome Analysis
25 Center Agriculture Food Environment
26 UNITN - Università degli Studi di Trento = University of Trento
27 Food Microbial Systems Research Division
28 Else Kröner Fresenius Center for Nutritional Medicine
29 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
30 ZIEL Institute for Food and Health
31 Departments of Biological Sciences and Computing Science
H. Daniel
- Fonction : Auteur
- PersonId : 937694
- IdHAL : herve-daniel
- ORCID : 0000-0003-1522-9556
Stéphanie Durand
- Fonction : Auteur
- PersonId : 736394
- IdHAL : stephanie-durand2
- ORCID : 0000-0002-9250-5537
- IdRef : 118436511
Franck Giacomoni
- Fonction : Auteur
- PersonId : 181685
- IdHAL : giacomoni-franck
- ORCID : 0000-0001-6063-4214
- IdRef : 253126916
P. Giesbertz
- Fonction : Auteur
- PersonId : 792999
- ORCID : 0000-0001-7461-8602
Claudine Manach
- Fonction : Auteur
- PersonId : 736225
- IdHAL : claudine-manach
- ORCID : 0000-0003-1094-3363
- IdRef : 230917623
Carole Migné
- Fonction : Auteur
- PersonId : 737879
- IdHAL : carole-migne
Estelle Pujos-Guillot
- Fonction : Auteur
- PersonId : 741275
- IdHAL : estelle-pujos-guillot
- ORCID : 0000-0002-4693-5712
- IdRef : 08151557X
Résumé
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state-of-the-art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative "A Healthy Diet for a Healthy Life" (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful "tips and tricks" along the analytical workflow.
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