The aim of this paper is to quantify peakflow attenuation and/or amplification in a river, investigating lateral flow from the intermediate catchment during floods. This is a challenge for the study of the hydrological response of permeable/intermittent streams, and our contribution refers to a modelling framework based on the inverse problem for the diffusive wave model applied in a karst catchment. Knowing the upstream and downstream hydrographs on a reach between two stations, we can model the lateral one, given information on the hydrological processes involved in the intermediate catchment. The model is applied to 33 flood events in the karst reach of the Iton River in French Normandy where peakflow attenuation is observed. The monitored zone consists of a succession of losing and gaining reaches controlled by strong surface-water/groundwater (SW/GW) interactions. Our results show that despite a high baseflow increase in the reach, peakflow is attenuated. Model application shows that the intensity of lateral outflow for the flood component is linked to upstream discharge. A combination of river loss and overbank flow for highest floods is proposed for explaining the relationships. Our approach differentiates the role of outflow (river loss and overbank flow) and that of wave diffusion on peakflow attenuation. Based on several sets of model parameterization, diffusion is the main attenuation process for most cases, despite high river losses of up to several m(3)/s (half of peakflow for some parameterization strategies). Finally, this framework gives new insight into the SW/GW interactions during floods in karst basins, and more globally in basins characterized by disconnected river-aquifer systems.